The Australian Charter of Employment Rights: The missing dimensions

Just prior to the 2007 General Election, a group of labour lawyers and economists, broadly sympathetic to the Labor Party, produced a Charter of Employment Rights. This article examines the Charter's proposals and its underlying framework, and suggests significant aspects of work and labour have been omitted. It contends that the Charter would have been improved if it had not retained an artificially stretched definition of workers as employees, in which the only relationship worthy of inclusion in a Charter is that between the direct employer and employee. The framework and language of the Charter convey a paternalistic approach and an outdated focus on industrial labour, while ignoring aspects of the emerging global system of work linked to the concept of occupation

Increasing profit on dairy farms

Farmers continually make decisions on all aspects of their farms that influence profit. For dairy farmers these include the number of cows, calving pattern, level and type of supplementary feeding, area of each pasture type and fodder crop, and the areas for hay or silage, or both. The extent and type of the beef sideline operations also influence the overall profitability of the farm. The WesternAustralian Dairy Farm Model (WADFM) is a whole farm model developed by the Western Australian Department of Agriculture to help farmers maximise profits by considering all effects of such decisions on the farm

Feelings of dual-insecurity among European workers: A multi-level analysis

This article analyses European Social Survey data for 22 countries. We assess the relationship between feelings of employment and income insecurity (dual-insecurity) among workers and national flexicurity policies in the areas of lifelong learning, active labour market policy, modern social security systems and flexible and reliable contractual arrangements. We find that dual-insecurity feelings are lower in countries that score better on most flexicurity polices, but these effects are in all cases outweighed by levels of GDP per capita. Thus feelings of insecurity are reduced more by the affluence of a country than by its social policies. However, affluence is strongly correlated with the policy efforts designed to reduce insecurity, especially active labour market policies and life-long learning, two policy areas that are threatened with cuts as a result of austerity

Does environmental enrichment while studying improve recall?

Previous research suggests that studying audio and visual stimuli in two different rooms increases verbal recall, as compared to studying twice in only one room (Smith, Glenberg, & Bjork, 1978). The present study utilized this paradigm, and also separated the room and modality factors as sources of environmental enrichment. In Experiment 1, subjects learned a list of 40 common English words twice, in either one or two different rooms, and were tested in a third room (N = 60). In Experiment 2, subjects learned the same word lists, using either one or two modalities (audition and vision), and again were tested in a third environment (N = 59). As predicted from the theory of Smith and Vela (2001), the usual improvement in memory from either room or modality enrichment did not occur when short time intervals were used between learning and recall, and the mean recall scores were essentially identical. The enrichment effect is interpreted as involving the development of categorized memory information over time, thus enabling retrieval strategies to operate, rather than an increase in the strength of initial learning

Safety of clonidine used for long-term sedation in paediatric intensive care: A systematic review

AIM: Although not approved, the α-adrenoceptor agonist clonidine is considered an option for long-term sedation protocols in paediatric intensive care. We reviewed adverse effects of clonidine occurring in this indication. METHODS: Relevant literature was systematically identified from PubMed and Embase. We included interventional and observational studies on paediatric patients admitted to intensive care units and systemically long-term sedated with clonidine-containing regimes. In duplicates, we conducted standardised and independent full-text assessment and extraction of safety data. RESULTS: Data from 11 studies with 909 patients were analysed. The studies were heterogeneous regarding patient characteristics (age groups, comorbidity, or comedication) and sedation regimes (dosage, route, duration, or concomitant sedatives). Just four randomised controlled trials (RCTs) and one observational study had comparison groups, using placebo or midazolam. For safety outcomes, our validity evaluation showed low risk of bias only in three studies. All studies focused on haemodynamic problems, particularly bradycardia and hypotension. Observed incidences or subsequent interventions never caused concerns. However, only two RCTs allowed meaningful comparisons with control groups. Odds ratios showed no significant difference between the groups, but small sample sizes (50 and 125 patients) must be considered; pooled analyses were not reasonable. CONCLUSION: All evaluated studies concluded that the use of clonidine in paediatric intensive care units is safe. However, a valid characterisation of the safety profile remains challenging due to limited, biased and heterogeneous data and missing investigation of long-term effects. This evaluation demonstrates the lack of data, which prevents reliable conclusions on the safety of clonidine for long-term sedation in critically ill children. For an evidence-based use, further studies are needed

Revising Pediatric Vancomycin Dosing Accounting for Nephrotoxicity in a Pharmacokinetic-Pharmacodynamic Model

This study aimed to suggest an initial pediatric vancomycin dose regimen through population pharmacokinetic-pharmacodynamic modeling. A population pharmacokinetic approach was used to analyze vancomycin concentration-time data from a large pediatric cohort. Pharmacokinetic target attainment for patients with bloodstream isolates was compared with clinical outcome using logistic regression and classification and regression trees. Change in serum creatinine during treatment was used as an indicator of acute nephrotoxicity. Probability of acute kidney injury (50% increase from baseline) or kidney failure (75% increase from baseline) was evaluated using logistic regression. An initial dosing regimen was derived, personalized by age, weight, and serum creatinine, using stochastic simulations. Data from 785 hospitalized pediatric patients (1 day to 21 years of age) with suspected Gram-positive infections were collected. Estimated (relative standard error) typical clearance, volume of distribution 1, intercompartmental clearance, and volume of distribution 2 were (standardized to 70 kg) 4.84 (2.38) liters/h, 39.9 (8.15) liters, 3.85 (17.3) liters/h, and 37.8 (10.2) liters, respectively. While cumulative vancomycin exposure correlated positively with the development of nephrotoxicity (713 patients), no clear relationship between vancomycin area under the plasma concentration-time curve and efficacy was found (102 patients). Predicted probability of acute kidney injury and kidney failure with the optimized dosing regimen at day 5 was 10 to 15% and 5 to 10%, increasing by approximately 50% on day 7 and roughly 100% on day 10 across all age groups. This study presents the first data-driven pediatric dose selection to date accounting for nephrotoxicity, and it indicates that cumulative vancomycin exposure best describes risk of acute kidney injury and acute kidney failure